I just recently was put on Amoxicilin 850 mg twice daily for an abscessed tooth that I had root canal on. About 72 hours later, I developed severe hives on my neck, chest, abdomen back and face. My doctor stopped the medicine and put me on another antibiotic. He wanted me to take 50 mg of Benadryl three times a day. Since it is the evening and my ADD med, (Vyvanse), probably wore off, I took a dose of Benadryl tonight. I was wondering if anyone ever took Benadryl with their ADD meds. These hives are awlful and very itchy. I am afraid about a drug interaction taking the two together. I thought if I have to take the Benadryl tomorrow, I would not take my ADD meds since I don't have to go to work. I figure it would be better to take one or the other and not both meds together to be safe. Anyone have any experience with these 2 meds together?